BDBM50190709 8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-propyl-1H-purine-2,6(3H,7H)-dione::8-[4-(4-benzylpiperazide-1-sulfonyl)phenyl]-1-propylxanthine::CHEMBL212625

SMILES CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(Cc2ccccc2)CC1

InChI Key InChIKey=HHNGYTVWOXXKET-UHFFFAOYSA-N

Data  22 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50190709   

TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50190709(8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-pro...)
Affinity DataKi:  1.33nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50190709(8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-pro...)
Affinity DataKi:  3.60nMAssay Description:Antagonist activity against human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50190709(8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-pro...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50190709(8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-pro...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50190709(8-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1-pro...)
Affinity DataIC50:  10.1nMAssay Description:Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed